|
KMID : 0370220080520050384
|
|
Yakhak Hoeji
2008 Volume.52 No. 5 p.384 ~ p.393
|
|
|
Improvement of Memory Impairment of Green Tea Extract/L-Theanine Through Inhibition of Secretase Activity and Cell Death In Vivo
|
|
Kim Tae-Il
Yuk Dong-Yeon
Park Sang-Ki
Park Hyoung-Kook
Yoon Yeo-Kyeung
Hong Jin-Tae
|
|
|
Abstract
|
|
|
|
We examined the effect of green tea extract (GTE) and L-theanine combination on the Aβ1-42-induced memory dysfunction. GTE and combination were administrated into mice for 3 weeks followed by injection of Aβ1-42 to induce memory impairment. GTE and L-theanine administration significantly improved cognitive ability and reduced Aβ1-42 level accompanied with the inhibition of neuronal cell death and activities of secretase. These results suggest that GTE and L-theanine combination may be a useful for preventing for the development or progression of Alzheimer’s disease.
|
|
|
KEYWORD
|
|
|
green tea extract, L-theanine, Alzheimer’s disease, memory, secretase, amyloid beta, cell death
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|